Rajinikanth

Padayappa

Sivaji Ganesan

Padayappa's Father

Ramya Krishnan

Neelambari

Soundarya

Vasundhara

Lakshmi

Padayappa's Mother

Sithara

Padayappa's Sister

Radha Ravi

Neelambari's Father

Nassar

Surya Prakash

Manivannan

Padayappa's Father's Foster Brother

Senthil

Alagapuri Azhagesan

Abbas

Chandraprakash

Preetha Vijayakumar

Anitha

Ramesh Khanna

Padayappa's friend

Vadivukarasi

Padayappa's Friend

Mansoor Ali Khan

Krishnasamy Mudaliar

Prakash Raj

Police Officer Subramaniam (Special Appearance)

Vasu Vikram

Padayappa's cousin

Raja Ravindra

Padayappa's cousin

Rajesh Kumar

Lavanya

Suryapraksh's Wife

Mohan Raman

Lawyer

Ravi Raghavendra

Ravi Chellaiah

Scissor Manogar

Kanal Kannan

Farmer told by Neelambari to kill the snake (uncredited)

Mahendran

Guest at Anitha's birthday (uncredited)

Robo Shankar

Dancer in the song "En Peru Padayappa" (uncredited)

Aravind Akash

Dancer in the song "En Peru Padayappa" (uncredited)

K. S. Ravikumar

Self (Cameo Appearence)